Discussing Body Iron is difficult and no single indicator
or combination of indicators is ideal for the assessment of
iron status in all clinical circumstances.
Each indicator may be affected by a variety of conditions
including infection, inflammation. Liver disease and
malignancy, and these factors must be considered in
interpreting laboratory investigations.
Iron is very important for sustaining good health. Iron
deficiencies can cause fatigue and make us more susceptible
to viruses, cancer and a variety of degenerative conditions.
Likewise, iron excess or alteration in the iron-binding
capability resulting in free, unbound iron carries the
potential for causing or aggravating all diseases,
infections, cancers and toxicities.
Therefore is it necessary that we do not only strive to
both acquire adequate amounts of iron and rid ourselves of
excess iron, and that every effort is made to bind and
properly escort iron from the moment it enters the body
until it exits. In addition, binding and escorting iron is
particular important during the detoxification
process.Otherwise, the many benefits iron provide are
easily overshadowed by its toxicity.
Iron is essential to life, because of its unique ability to
serve as both an electron donor and acceptor. But iron can
also be potentially toxic. Iron's ability to donate and
accept electrons means that if iron is free within the
cell, it can catalyze the conversion of hydrogen peroxide
into free radicals. And free radicals can cause damage to a
wide variety of cellular structures, and ultimately kill
the cell.
To prevent that kind of damage, all life forms that use
iron bind the iron atoms to proteins. That allows the cells
to use the benefits of iron, but also limit its ability to
do harm.
Many proteins are enzymes that catalyze biochemical
reactions, and are vital to metabolism.
The words protein, polypeptide, and peptide are a little
ambiguous and can overlap in meaning.
Protein is generally used to refer to the complete
biological molecule in a stable conformation, whereas
peptide is generally reserved for a short amino acid
oligomers often lacking a stable 3-dimensional structure.
However, the boundary between the two is ill-defined and
usually lies near 20-30 residues.
Polypeptide can refer to any single linear chain of amino
acids, usually regardless of length, but often implies an
absence of a defined conformation
The iron withholding mechanism occurs naturally at the
onset of every healthy, acute inflammatory response. Given
full recognition to the natural defence mechanism of iron
withholding allows health professionals to be far more
effective when building immunity, treating people for
cancer, iron deficiency, inflammation, excessive tiredness,
memory decline or depression.
The risk in amplified when laboratory testing is
inadequate; typical of many insurance driven health plans.
Similarly, there is risk in supplementing iron where the
decision to supplement is based solely on a low serum iron
reading.
To give an example, when in the chemistry it shows up that
a person has low serum iron, an elevated to high
Transferrin Iron Binding Capacity and a low Transferrin
Saturation, this is an indicator that there is free iron.
It also indicates that there is a Copper Deficiency.
Cerruloplasmin is a specialized copper-rich protein that
enters the Ferritin molecule to free iron, so it can be
attached to transferrin.
This is a pretty good marker, when it gets elevated, of a
copper deficiency. Remember that the Cerruloplasmin is the
copper bound protein or protein bound copper is the
compound that pulls the iron out of the ferritin cage, puts
it out on to the transferrin leash and attaches it to the
leash.
If the Cerruloplasmin are not there then of course you can
have a lot of transferrin in the serum without the iron
molecules being attached to the leash.
Each one of these transferrins has two hooks on them so you
can put two irons on each leash but if the copper is not
there, if you are deficient and can't make the
Cerruloplasmin, what happens Transferrin Iron Binding
Capacity rises because you don't have iron actually
attached to enough of the transferrins.
When there is free iron, this also indicates that the iron
is not bound to the protein. One of the consequences of the
depleted amino acids pool is that this has an impact on the
neurotransmitters.
Therefore it could be helpful to access the iron status as
discussed and the amino acid pool.
The diagnosis of Clinical Depression could be dealt with an
additional different protocol, which might lead to better
outcomes.
By identifying the markers for disturbed iron status and
assisting you in developing a comprehensive strategy for
achieving a healthy iron status your risk of all disease
and toxicity and infection are lessened.
In addition to accurately measuring iron levels, strategies
for restoring iron balance need to take into account many
factors.
1. Maintaining a healthy intestinal mucosa
2. Sustaining adequate protein levels
3. Sustaining and aerobic versus anaerobic metabolism
4. Achieving a state of alkalinity versus acid stress
5. Maintaining a healthy cytochrome P450 system to rid the
body of organic solvents and other toxins that may hinder
protein-iron binding
6. Establishing a diet rich in whole eggs and cultured
dairy for individuals with a tendency towards free iron,
iron overload.
7. Recommending a phlebotomy program for those confirmed
with iron overload.
Transferrin, lactoferrin, lactoglobin and ovotransferrin
are iron-binding proteins.
Transferrin, the only commonly measured iron-binding
protein that is synthesized by the body, is readily taken
up by receptors of both healthy cells and cancer cells.
Lactoferrin and lactoglobin, derived from dairy foods, plus
ovotransferrin (conalbumin) from eggs binds tightly to free
iron
----------------------------------------------------
http://www.apneasleep-snoringtreatments.com
http://www.a-holistic-healthcoach-approach.com
Information about Free Radical Therapy can be obtained in
website http://www.apneasleep-snoringtreatments.com
Helena Ederveen, Clinical Nutritionist, has worked with the
biochemistry analysis based upon the Free Radical Therapy
for 6 years.
Life Style changes are required in order to influence
changes in the biochemsitry
No comments:
Post a Comment