Drug against pain and arthritis Celebrex - Important facts

Drug against pain and arthritis Celebrex - Important facts
Celebrex is prescribed for acute pain, menstrual cramps,
and the pain and inflammation of osteoarthritis and
rheumatoid arthritis. It is a member of a new class of
nonsteroidal anti-inflammatory drugs (NSAIDs) called COX-2
inhibitors.

Like older NSAIDs such as Motrin and Naprosyn, Celebrex is
believed to fight pain and inflammation by inhibiting the
effect of a natural enzyme called COX-2. Unlike the older
medications, however, it does not interfere with a similar
substance, called COX-1, which exerts a protective effect
on the lining of the stomach.

Therefore, Celebrex may be less likely to cause the
bleeding and ulcers that sometimes accompany sustained use
of the older NSAIDs.

Celebrex has also been found to reduce the number of
colorectal polyps (growths in the wall of the lower
intestine and rectum) in people who suffer from the
condition called familial adenomatous polyposis (FAP), an
inherited tendency to develop large numbers of colorectal
polyps that eventually become cancerous.

*** Most important fact about Celebrex

Like other NSAID medication, Celebrex could increase the
chance of having a heart attack or stroke, possibly
resulting in death. The risk is greater if you have heart
disease or use NSAIDs for a long time. It's important to
discuss the risks and benefits of using Celebrex with your
doctor and to use the lowest effective dose for the
shortest amount of time possible.

Although Celebrex is easy on the stomach, it still poses
some degree of risk—especially if you've had a stomach
ulcer or gastrointestinal bleeding in the past. All NSAIDs,
including Celebrex, can cause serious—and even
life-threatening—ulcers and bleeding in the stomach and
intestines.

These side effects can happen without symptoms and may
occur at any time during treatment. If you've ever had
ulcers or stomach bleeding, make sure the doctor is aware
of it. And be sure to alert the doctor if you develop any
digestive problems or notice a change in your bowel
movement (such as blood in the stool or black, sticky
stools).

* Side effects

Side effects cannot be anticipated. If any develop or
change in intensity, inform your doctor as soon as
possible. Only your doctor can determine if it is safe for
you to continue taking Celebrex.

Side effects may include:

Abdominal pain, diarrhea, headache, indigestion, nausea,
respiratory infection, sinus inflammation.

Do not take Celebrex right before or after heart bypass
surgery (also called coronary artery bypass graft, or CABG).

In addition, you should not use Celebrex if you are
allergic to sulfonamide drugs such as sulfadiazine,
sulfisoxazole, Gantanol, and Thiosulfil. Also avoid the
drug if you've ever suffered an asthma attack, face and
throat swelling, or skin eruptions after taking aspirin or
other NSAIDs. If you find that you are allergic to
Celebrex, you will not be able to use it.

Also alert your doctor if you develop any digestive
problems, swelling, or rash. The chance of developing a
stomach ulcer or bleeding while taking Celebrex increases
if you also take steroid drugs or blood thinners, smoke,
drink alcohol, or use Celebrex or other NSAID medications
for a long time. The risk is also greater if you're older
or in poor health.

If you have asthma, use Celebrex with caution. It could
trigger an attack, especially if you are also sensitive to
aspirin.

If you are taking a steroid medication for your arthritis,
do not discontinue it abruptly when you begin therapy with
Celebrex. Celebrex is not a substitute for such drugs.

Celebrex has been known to cause kidney or liver problems,
particularly in people with an existing condition. If you
have such a disorder, take Celebrex with caution. If you
develop symptoms of liver poisoning, stop taking the drug
and see your doctor immediately. Warning signs include
nausea, fatigue, itching, yellowish skin, pain in the right
side of the stomach, and flu-like symptoms.

If you are prone to anemia (loss of red blood cells), make
sure the doctor knows about it. Celebrex occasionally
fosters this problem.

Celebrex sometimes causes water retention, which can
aggravate swelling, high blood pressure, and heart failure.
Use Celebrex with caution if you have any of these
conditions.

There is no proof that Celebrex reduces the odds of cancer
in people who take the drug for FAP. Although Celebrex can
reduce the number of growths, you'll still need the other
treatments and frequent checkups that this condition
requires.

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